The role earned him a nomination for the Best Actor New Zealand Television Award. From 1997 to 2001 Mesure starred in the series Xena: Warrior Princess. From 2000 to 2003 he starred as Kees Van Dam in the TV series Street Legal for which he won a Best Supporting Actor Award at the New Zealand Film and TV Awards. From 2005 to 2007 Mesure starred as J.D. Pollack in the series Crossing Jordan. From 2009 to 2010 he starred as Zane Gerard in the series Outrageous Fortune and in 2010 as Alec Ross in This is Not My Life. Charles starred as Kyle Hobbes in the TV series V and as Ben Faulkner in the series Desperate Housewives.