He grew up in Tampa, Florida and formed Deicide with guitarist Ben Hoffman in 1987. The group has been the subject of bans, criticism, and lawsuits from religious groups as well as the general public for their lyrics. They released their self-titled debut studio album in 1990 and have released a total of 11 albums. Glen Benton has been featured on two albums by Vital Remains and has made guest appearances with artists including Cancer, Cannibal Corpse, Napalm Death, Transmetal, Roadrunner United, and Belphegor.