Hilario has played in more than 50 postseason games, most with the Nuggets between 2004 and 2011. In 2008, he announced he was taking a leave from the game to deal with a medical issue. Hilario returned two months later after having surgery to remove a tumor on his testicles. He has been married to his wife, Lauren Prothe, since 2009. After his retirement, Hilario hopes to form relationships with churches and the youth Christian community when he returns to his home country. As of September 2018, Nene Hilario has earned $123 million in NBA salary alone.