From 2007 to 2013 he co-presented the daytime TV series Real Rescues. Nick Knowles has also been featured on the TV series Ridge Riders, 5’s Company, Last Choir Standing, Guesstimation, Wildest Dreams, Secret Fortune, Perfection, Close Calls: On Camera, The Retreat, and more. In 2018 he competed on the reality TV series I’m a Celebrity… Get Me Out of Here!. Knowles co-wrote and executive produced the movie Golden Years.