She enrolled in makeup courses at the B Academy in Amsterdam and later signed to Colourfool Agency as a professional makeup artist. She joined the TV series I Can Make You a Supermodel as the head makeup artist in 2013. She has collaborated with beauty brands including Maybelline, Too Faced, and Ofra. Nikkie de Jager won a 9th Annual Shorty Award in 2017 for YouTube Guru and won a Teen Choice Award in 2017 for Choice Web Star: Fashion/Beauty.
