Melvin has starred in the movies Boo, My Funny Valentine, Zombeavers, Dumb and Dumber To, and Bad Fan. She has also appeared in episodes of the TV series Summerland, Jack & Bobby, 8 Simple Rules, Heroes, Seven Deadly Sins, House M.D., and Good Luck Charlie. Melvin was nominated for Daytime Emmy Awards for Outstanding Younger Actress in a Drama Series for Days of Our Lives in 2008 and 2009.